Sioux Falls, South Dakota appears in the CMS National Plan and Provider Enumeration System with 6,350 registered healthcare providers spanning 20 distinct NUCC-taxonomy specialties. This count includes every individual clinician who has applied for an NPI and listed a practice address in Sioux Falls - physicians, dentists, nurse practitioners, physician assistants, chiropractors, physical therapists, optometrists, psychologists, podiatrists, and every other credentialed provider type CMS tracks. It does not measure hospital beds, urgent-care capacity, or whether a given clinic is accepting new patients; it measures the pool of professionals with current NPI enrollment and a Sioux Falls practice location on file. Every figure is drawn from the federal National Provider Identifier Registry (CMS NPPES) - more than 7 million providers, maintained since May 2007, with 2023 Medicare Part D data, and, according to CMS, can be searched, compared, and traced in our methodology.

The provider mix in Sioux Falls is weighted toward Pharmacist (354 clinicians, followed by Student in an Organized Health Care Education/Training Program with 315 and Family Nurse Practitioner with 293). That distribution reflects how NPPES records specialty: providers self-select a primary taxonomy code, so a family physician who also practices geriatrics will show up under whichever NUCC code they registered first. Relative to South Dakota's population, Sioux Falls reports roughly 690.7 providers per 100,000 residents using the state-level denominator, which is a rough proxy rather than a precise access-to-care measurement; the true catchment area of any {cityName} clinician extends beyond the municipal boundary.

For Sioux Falls patients, this directory is most useful as a starting shortlist. Important: PlainDoctor is a directory of publicly available CMS government data, not a review site, a ranking, or medical advice. NPPES data is self-reported and refreshed monthly; call the practice directly to confirm the provider is still there, accepts your insurance, and is taking new patients.