The CMS National Plan and Provider Enumeration System currently lists 2,214 Physician Assistant providers with a primary practice address in South Carolina. Each clinician on this roster selected Physician Assistant as their primary taxonomy at NPI enrollment — a self-reported classification that is updated whenever the provider files a correction with CMS. The count excludes organizations (group practices, hospitals, clinics operate under separate NPIs) and excludes providers who chose a different primary specialty even if they practice Physician Assistant part-time.

At 2,214 enrolled providers, Physician Assistant in South Carolina is a mid-volume market — that matters for search-radius decisions, because patients in South Carolina outside the largest metros often need to broaden to adjacent cities to find a local Physician Assistant clinician. The directory below is paginated 50 providers at a time (45 pages total) and is sorted alphabetically by last name, so scanning for a specific practice usually goes faster than scrolling; on the provider detail page you'll find the full NPPES record including address, phone, credentials, and any published Medicare Part D prescribing activity for 2023.

Before contacting anyone on this list, verify the practice is still at the address shown — NPPES refreshes monthly, but providers who have relocated, retired, or changed employers may not have filed an NPI update yet. Important: PlainDoctor is a directory of publicly available CMS government data covering Physician Assistant providers in South Carolina, not a quality ranking, a board-certification verifier, or medical advice. Always confirm credentials through the NPPES NPI Registry, the South Carolina medical board, and — where relevant — the ABMS, AOA, or the specialty's primary certifying body before making any clinical decision. Nothing on this page substitutes for a conversation with a licensed clinician.